Contraceptive methods

A - Human Necessities – 61 – K

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167/272, 128/51

A61K 31/155 (2006.01)

Patent

CA 1254516

i ABSTRACT This invention relates to the use of a bisbiguanide compound of the formula:- R1R2N.C(:NH)N:C(NH2)N-A-N.C(NH2):N.C(:NH)NR3R4 wherein either: (i) R1 and R3, which may be the same or different, are each a phenyl radical which is substituted by alkyl, alkoxy, nitro or halogen, R2 and R4 are both hydrogen, and A is a 3-9C polymethylene diradical, wherein the polymethylene chain may be interrupted by oxygen atoms and/or by aromatic nuclei; or (ii) the bivalent bridge A is: (a) alkylene of from 2 to 12 carbon atoms having the valence bonds attached to different carbon atoms, (b) -(CH2)m-X-(CH2)n- wherein m and n each represent an integer from 2 to 6 and Y is O or S, (c) Image (d) Image wherein Z and Z are each alkylene of from 1 to 3 carbon atoms, ii (e) Image wherein Q is -O-, -S-, -SO- or -SO2-, (f) Image R1 and R3 are each: (a) alkyl of from 6 to 16 carbon atoms, or (b) alkyl-Y-alkylene, wherein Y is O or S and the alkyl and alkylene radicals together contain 3 to 15 carbon atoms; and R2 and R4 are each hydrogen or 1-6C alkyl; or an acid addition salt thereof.

465014

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