Contrast agent-enhanced magnetic resonance imaging of tissue...

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Patent

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Details

G01R 33/28 (2006.01) A61B 5/055 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2296572

This invention relates to a method of contrast agent-enhanced magnetic resonance imaging of perfusion in vasculated tissue within a human or non- human animal body in which a bolus comprising a contrast-enhancing amount of a magnetic resonance imaging contrast agent is administered into the vascular system of said body, and said body is subjected to a magnetic resonance imaging procedure whereby signals or images representative of first pass of said contrast agent bolus through tissue of interest are generated, characterised in that (i) said contrast agent is capable of exhibiting simultaneous, determinable T1 and T2* reducing effects under the imaging procedure employed and (ii) a T1-weighted imaging procedure is used (a) to visualise the first pass of said contrast agent bolus through said tissue by virtue of its signal lowering T2* effect and (b) to obtain a T1-weighted contrast agent-enhanced image of said tissue.

L'invention se rapporte à un procédé d'imagerie par résonance magnétique, améliorée par un agent de contraste, d'une perfusion opérée dans un tissu vascularisé d'un corps humain ou animal. Selon ce procédé, on administre dans le système vasculaire dudit corps un bolus contenant une quantité améliorant le contraste d'un agent de contraste, puis on soumet ce corps à une procédure d'imagerie par résonance magnétique pendant laquelle on génère des images ou des signaux représentatifs du premier passage du bolus d'agent de contraste à travers le tissu étudié. La procédure d'imagerie employée est caractérisée en ce que: (1) l'agent de contraste peut manifester des effets réducteurs de T¿1? et de T¿2?* simultanés et pouvant être déterminés et (2) on utilise une procédure d'imagerie pondérée en T¿1? pour (a) visualiser le premier passage du bolus d'agent de contraste à travers le tissu grâce à l'effet de réduction de signal du T¿2?* et pour (b) obtenir une image du tissu pondérée en T¿1? et améliorée par un agent de contraste.

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