Contrast agents containing two types of gas filled microbubbles

A - Human Necessities – 61 – K

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Details

A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2278750

Ultrasound contrast agents comprising two or more types of gas-containing microparticles which differ in their susceptibility to ultrasonic pressure. Microparticle types having relatively low susceptibility to ultrasonic pressure provide a response to high acoustic energy in the near field where microparticle types with relatively high susceptibility tend to be inactivated through destruction. More highly susceptible microparticle types are effective in the lower acoustic energy environment of the far field, where lower susceptibility microparticle types will tend to exhibit little interaction.

L'invention concerne des agents de contraste contenant deux ou plusieurs types de microparticules remplies de gaz qui diffèrent quant à leur sensibilité à la pression ultrasonore. Les types de microparticules qui ont une sensibilité à la pression ultrasonore relativement faible réagissent à une énergie acoustique élevée dans le champ proche tandis que les types de microparticules de sensibilité relativement élevée tendent à être inactivés par destruction dans les mêmes conditions. Les types de microparticules de sensibilité plus élevée sont efficaces dans l'environnement inférieur de l'énergie acoustique du champ éloigné, les types de microparticules de sensibilité plus faible tendent à montrer une faible interaction dans les mêmes conditions.

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