Contrast agents for nmr imaging

Details Contrast agents for nmr imaging Contrast agents for nmr imaging

A - Human Necessities

61

K

167/46

A61K 49/00 (2006.01) A61K 49/18 (2006.01) G01R 33/28 (2006.01)

Patent

CA 1245553

ABSTRACT OF THE DISCLOSURE An agent for contrast enhancement in nuclear magnetic resonance imaging is disclosed. Vesicles such as phospholipid vesicles are associated with or enclose a paramagnetic material. The vesicles may be formulated with an agent, such as cholesterol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.

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