Contrast agents for ultrasonic imaging and method of use

A - Human Necessities – 61 – K

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167/46

A61K 49/00 (2006.01) A61B 8/00 (2006.01) A61K 49/22 (2006.01) A61B 19/00 (2006.01)

Patent

CA 1274773

ABSTRACT OF THE DISCLOSURE A method of ultrasonic imaging for use in medical pro- cedures is disclosed. The method comprises providing specifically defined microbubbles formed by sonicating a biocompatible liquid comprising a sonicated aqueous protein solution, preferably a 5% solution of human serum albumin, and denaturing the protein therein by heat or chemical methods; injecting the microbubbles into an animal or human to thereby alter the acoustic properties of an area to be imaged; and then ultrasonically scanning the area so as to obtain an ultrasound scanning image.

524419

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