A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/22 (2006.01) A61K 9/127 (2006.01) A61K 47/04 (2006.01) A61K 47/24 (2006.01)
Patent
CA 2262908
Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilised by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.
Les milieux de contraste pour imagerie aux ultrasons de la présente invention comportent des microbulles de gaz biocompatible, du type halogénure de soufre ou perfluorocarbone, stabilisées par une matière amphiphile susceptible de subir une opsonisation, telle qu'un lipide susceptible de former une membrane, du type phospholipide, notamment un phospholipide chargé négativement tel que la phosphatidylsérine. Ces milieux de contraste peuvent se caractériser par un temps de séjour prolongé s'agissant de la génération du contraste dans le foi à la suite d'une administration intraveineuse.
Braenden Jorunn
Dugstad Harald
Eriksen Morten
Frigstad Sigmund
Johnson David
Fetherstonhaugh & Co.
Ge Healthcare As
Nycomed Imaging As
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