Contrast agents to target extracellular matrix

Details Contrast agents to target extracellular matrix Contrast agents to target extracellular matrix

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2586621

A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.

L'invention concerne un agent de contraste représenté par la formule générale Z1-L-V-Z2 (I), dans laquelle Z1 et/ou Z2 sont présents et représentent des fragments de gènes rapporteurs identiques ou différentes détectables dans l'imagerie in vivo du corps humain ou animal, V représente un fragment de ciblage présentant une affinité de liaison pour des zones de formation de collagène, L représente une liaison covalente, un modificateur biologique ou une fraction de liant.

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