Contrast resolution tissue mimicking phantoms for nuclear...

Details Contrast resolution tissue mimicking phantoms for nuclear... Contrast resolution tissue mimicking phantoms for nuclear...

G - Physics

01

N

324/1

G01N 24/08 (2006.01) G01R 33/58 (2006.01)

Patent

CA 1311520

CONTRAST RESOLUTION TISSUE MIMICKING PHANTOMS FOR NUCLEAR MAGNETIC RESONANCE IMAGING ABSTRACT OF THE DISCLOSURE Tissue mimicking phantoms for NMR imagers are produced having a base tissue mimicking material enclosed within a sealed container. The base tissue mimicking material comprises a gel which has been solidified from a mixture of agar, animal hide gelatin, water, glycerol, and anti-bacterial agents such as n-propanol, p-methylbenzoic acid, and formaldehyde. The formaldehyde also serves to cross link the animal hide gel and thereby raise the melting point of the tissue mimicking material to a temperature well above normal ambient temperatures. This base tissue mimicking material is stable both in dimensions and NMR properties over long periods of time. Contrast resolution inclusions are formed within the base tissue mimicking material which have T1, T2, or both which differ from the corresponding values for the base tissue mimicking material, thereby allowing these inclusions to be imaged and distinguished from the surrounding material. The inclusions simulate tumors in normal tissue, and are preferably formed in a variety of sizes down to very small diameter spherical objects which at or beyond the imaging capability of the NMR imaging apparatus. Inclusions which are stable in size, shape and NMR properties over time while in direct contact with the base tissue mimicking material without the need for a barrier can be formed of the same solidified gel material as the base tissue mimicking material but differing in the dry weight concentration of agar. Several sets of inclusions may be formed having differing dry weight concentrations of agar in each set so that each set will have a different level of contrast with the base tissue mimicking material.

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