Control of calcium fluoride formation in mouth rinses,...

A - Human Necessities – 61 – K

Patent

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A61K 8/55 (2006.01) A61K 8/21 (2006.01) A61K 8/24 (2006.01) A61K 8/365 (2006.01) A61K 8/44 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2209556

Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.

On décrit des compositions spéciales et des procédés faisant appel à des inhibiteurs de la formation du fluorure de calcium. Le système d'apport du fluorure est à deux composants et il permet un certain retard contrôlé dans la réaction de formation (précipitation) du fluorure de calcium, ce qui permet d'améliorer le dépôt du fluorure de calcium au niveau de la cavité buccale. Un des deux composants du système d'apport du fluorure contient une source d'ions calcium et l'autre une source d'ions fluorure. Un inhibiteur de la formation du fluorure de calcium est présent dans un des deux composants ou dans les deux, de sorte que, quand ils sont mélangés, le fluorure de calcium ne se forme par précipitation qu'environ 5 secondes après le mélange. Le système peut être utilisé pour les bains de bouche, les dentifrices ou les gommes à mâcher.

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