Control of cci-779 dosage form stability through control of...

Details Control of cci-779 dosage form stability through control of... Control of cci-779 dosage form stability through control of...

A - Human Necessities

61

K

A61K 31/436 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2632239

A method of preparing a rapamycin composition having increased potency is provided. The method involves selecting a rapamycin compound having less than 1.5% oxidative and hydrolytic rapamycin impurities and formulating the selected rapamycin with an antioxidant and optional excipients.

La présente invention concerne un procédé de préparation d'une composition de rapamycine de puissance accrue. Le procédé consiste à choisir un composé de rapamycine contenant moins de 1,5 % d'impuretés d'oxydation et d'hydrolyse de la rapamycine, et à préparer la rapamycine choisie avec un antioxydant et éventuellement des excipients facultatifs.

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