Control of cd44 gene expression for therapeutic use

Details Control of cd44 gene expression for therapeutic use Control of cd44 gene expression for therapeutic use

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2228965

Neoplastic cells which over-express CD44, including especially non-small cell lung cancer and melanoma cancer cells, are treated with antisense oligonucleotides to control CD44 expression. Test results show that the claimed oligonucleotides significantly decreases cell growth in a CD44 sequence specific manner of lung cancer or melanoma cells, or both, but are largely non-toxic to normal cells. Examples of dosing in a clinical setting are provided.

Les cellules néoplasiques surexprimant CD44, en particulier celles des cancers du poumon non à petites cellules et celles de mélanomes malins, sont traitées avec des oligonucléotides antisens pour réguler l'expression de CD44. Les essais effectués montrent que les oligonucléotides revendiqués diminuent considérablement la croissance de cellules de cancer du poumon ou de cellules de mélanome ou les deux, d'une manière qui est liée à la diminution de la séquence CD44. Ces oligonucléotides sont, dans une large mesure, non toxiques pour les cellules normales. Des exemples de doses administrées en milieu clinique sont également donnés.

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