Control of function of intracellular ca ion

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61P 43/00 (2006.01) C07K 14/46 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2525696

Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.

La présente invention concerne l'analyse d'une substance capable de se lier avec le récepteur (IP¿3?R) d'inositol-1,4,5-triphosphate (IP3), de préférence avec un domaine de régulation de IP¿3?R. Cette invention concerne aussi l'établissement d'une technique de traitement ou de diagnostic de divers dysfonctionnements et de diverses maladies associées à IP¿3?R. Cette invention concerne en particulier la commande de l'activité de libération de Ca?2+¿ intracellulaire. Plus spécifiquement, un régulateur de l'activité du récepteur (IP¿3?R) de inositol-1,4,5-triphosphate (IP3), comprend une protéine associée à l'anhydrase carbonique (CARP), un agent de commande de libération du calcium intracellulaire constitué de protéine associée à l'anhydrase carbonique (CARP) et, une technique de commande utilisant ce dernier.

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