Control of gene expression

Details Control of gene expression Control of gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376166

A method of suppressing the expression of a selected gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a DNA binding portion which binds to a site at or associated with the selected gene which site is present in a plant or animal genome and a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide.

La présente invention concerne un procédé destiné à supprimer, dans une cellule eucaryote, l'expression d'un gène sélectionné, ce procédé consistant à introduire dans la cellule (a) un polypeptide comprenant une portion liante d'ADN, qui se lie à un site du gène sélectionné ou sur un site associé à ce gène, ce site étant présent dans un génome végétal ou animal, ainsi qu'une portion d'inactivation de chromatine, ou (b) un polynucléotide codant pour ce polypeptide.

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