Control of gene expression in a non-human eukaryotic cell,...

Details Control of gene expression in a non-human eukaryotic cell,... Control of gene expression in a non-human eukaryotic cell,...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2513336

The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. Specifically, the invention provides an isolated nucleic acid molecule comprising two or more copies of a ribonucleotide (RNA) sequence which are about 20-100 nucleotides in length and wherein a first copy is at least 80% identical to the nucleotide sequence of a target gene or a region thereof, and at least a second copy is 80% identical to a nucleotide sequence complementary to the target gene or the region thereof, wherein said nucleic acid molecule is capable of reducing expression of the target gene in a mammalian cell when the nucleic acid molecule is introduced into said mammalian cell.

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