Control of gene expression in eukaryotes

Details Control of gene expression in eukaryotes Control of gene expression in eukaryotes

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A01H 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2356125

A chemically inducible gene expression system is described. A chimaeric gene having a first sequence comprising a promoter and a regulator polypeptide is linked with a second sequence comprising a promoter and a coding or non-coding sequence. Expression of the target gene of the second sequence is controlled by the regulator polypeptide which is acted upon an inducer. The inducer is a chemical compound, such as OHP, which acts upon the OHP responsive regulator polypeptide, which can be obtained from Rhodococcus sp. V49. Various domain regions and complementary response elements are also described.

L'invention concerne un système d'expression génique pouvant être induit chimiquement. On lie un gène chimérique possédant une première séquence comprenant un promoteur et un polypeptide régulateur, avec une seconde séquence comprenant un promoteur et une séquence codante ou non codante. On régule l'expression du gène cible de la seconde séquence au moyen du polypeptide régulateur, lequel est commandé par un inducteur. Cet inducteur est un composé chimique, tel que OHP, qui agit sur le polypeptide régulateur sensible à OHP, et que l'on peut obtenir à partir de Rhodococcus espèce V49. L'invention concerne également diverses régions du domaine et divers éléments de réponse complémentaire.

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