Control of induced elevated intraocular pressure

Details Control of induced elevated intraocular pressure Control of induced elevated intraocular pressure

A - Human Necessities

61

K

A61K 31/567 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2620346

A variety of ocular diseases and conditions can be treated using corticosteroids or other compounds having glucocorticoid activity. A consequence of administration of such compounds is elevated intraocular pressure, which causes undesirable side-effects. The unwanted consequences of such elevated intraocular pressure may be prevented or treated through the administration of a steroid antagonist sufficient to counter the deleterious effect of the corticosteroid or other compound having glucocorticoid activity in the anterior chamber of the eye without countering the therapeutic effect of the treatment compound.

Selon l'invention, diverses maladies et affections oculaires peuvent être traitées au moyen de corticostéroïdes ou d'autres composés présentant une activité glucocorticoïde. Une conséquence de l'administration de ces composés est l'élévation de la pression intra-oculaire, phénomène qui provoque des effets secondaires indésirables. Les conséquences indésirables de cette élévation de la pression intra-oculaire peuvent être prévenues ou traitées par administration d'un antagoniste stéroïdien en dose suffisante pour supprimer les effets nuisibles du corticostéroïde ou d'un autre composé présentant une activité glucocorticoïde dans la chambre antérieure de l'oeil sans suppression de l'effet thérapeutique du composé thérapeutique.

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