C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2593872
The present invention relates to a method of identifying control sequences responding to an-timicrobial peptides (AMPs), to host cells expressing an AMP and comprising a control se-quence of the invention operable linked to a reporter, and to a method of screening for novel AMPs or AMP-variants having improved antimicrobial activity. Particularly the present inven-tion relates to DNA control sequences, wherein the transcriptional profiles of said control se-quences are regulated by the presence of an antimicrobial polypeptide expressed inside the host cell.
L'invention concerne une méthode d'identification de séquences de commande réagissant à des peptides antimicrobiens (AMP), des cellules hôtes exprimant un AMP et comprenant une séquence de commande de l'invention pouvant fonctionner lorsqu'elles sont reliées à un rapporteur, et une méthode de criblage de nouveaux AMP et de variants AMP présentant une activité antimicrobienne accrue. En particulier, l'invention concerne des séquences de commande d'ADN dans lesquelles les profils de transcription sont régulés par la présence d'un polypeptide antimicrobien exprimé à l'intérieur de la cellule hôte.
Christensen Bjarke
Hoegenhaug Hans-Henrik Kristensen
Nielsen Allan Kent
Nielsen Jesper Duus
Pedersen Poul Erik
Novozymes A/s
Novozymes Adenium Biotech A/s
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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