Controlled absorption of statins in the intestine

A - Human Necessities – 61 – K

Patent

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A61K 9/24 (2006.01)

Patent

CA 2588215

The present invention provides a controlled absorption formulation in which modified release of the active ingredient preferentially occurs in the lower gastrointestinal tract, including the colon. The formulation supports a significantly higher bioavailability of the active ingredient in the body of the subject than that can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core, over which an outer coating is layered. The core is optionally and preferably in the form of a tablet.

L'invention concerne une préparation à absorption commandée dans laquelle la libération modifiée de l'agent actif se produit de préférence dans le tractus gastro-intestinal inférieur, notamment le colon. Cette préparation soutient une biodisponibilité considérablement plus élevée de l'ingrédient actif dans le corps du sujet par rapport à une préparation conventionnelle utilisée actuellement, de façon que des concentrations plasmiques significatives au niveau thérapeutique de statine soient maintenues pour une durée étendue après administration. Cette préparation possède de préférence une partie centrale, sur laquelle est placée une couche extérieure. La partie centrale est éventuellement et de préférence sous forme de comprimé.

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