Controlled absorption of statins in the intestine

Details Controlled absorption of statins in the intestine Controlled absorption of statins in the intestine

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01) A61K 9/54 (2006.01) A61K 9/56 (2006.01) A61K 9/58 (2006.01) A61K 9/62 (2006.01)

Patent

CA 2603105

A delayed onset controlled release formulation is provided in which controlled release of the active ingredient occurs preferentially in the lower gastrointestinal tract including the colon. The formulation supports a significantly higher bioavailability of the active ingredient in the body of the subject than can be achieved from the currently used conventional formulation, such that therapeutically significant plasma levels of statin are maintained for an extended period after administration. The formulation preferably features a core, over which an outer coating is layered. The core is optionally and preferably in the form of a tablet.

L'invention concerne une préparation à libération régulée et à action retardée, la libération régulée du principe actif se produisant de préférence dans le tractus gastro-intestinal inférieur, y compris le côlon. Cette préparation permet d'accroître considérablement la biodisponibilité du principe actif dans le corps du sujet par comparaison avec celle pouvant être obtenue à partir de la préparation classique actuellement utilisée, de façon que des concentrations plasmatiques thérapeutiquement importantes en statine soient maintenues pendant une période prolongée après l'administration. Ladite préparation comprend de préférence un noyau sur lequel un enrobage extérieur est disposé en couches. Le noyau se présente éventuellement et préférablement sous la forme d'un comprimé.

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