A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/36 (2006.01) A61K 9/00 (2006.01) A61K 9/22 (2006.01) A61K 9/32 (2006.01)
Patent
CA 2500061
A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: - at least a biologically active ingredient, and - an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend with the said hydrophilic cellulose polymer, the weight ratio of the hydrophilic cellulose polymer to the amphiphilic material being from 0.2:1 to 0.6:1, provides improved sustained release of the biologically active ingredient.
L'invention porte sur un composite biologiquement actif sous forme solide comportant: (a) une couche extérieure, et (b) un noyau intérieur remplissant ladite couche extérieure et comprenant au moins un ingrédient biologiquement actif et un excipient composé d'au moins un polymère hydrophile de cellulose et un matériau amphiphile sous forme de mélange avec ledit polymère, le rapport pondéral polymère de cellulose/matériau amphiphile étant compris entre 0,2:1 et 0,6:1 assurant la libération continue de l'ingrédient biologiquement actif.
Mehuys Els
Remon Jean Paul
Vervaet Chris
Smart & Biggar
Universiteit Gent
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