A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/36 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2457308
A controlled release dosage form with variable release rates comprising: 1) a bilayer or multilayer tablet core in which at least one of the layers contains one or more pharmaceutically active ingredients and at least one of the layers contains one or more rate controlling polymers; 2) a substantially insoluble casing extended over the tablet core covering the majority of tablet surface but leaving a portion of one layer of the table core exposed (exposed layer), the casing resulting from electrostatic deposition of a powder comprising fusible particles onto the tablet core and fusing the particles to form a thin film.
L'invention concerne une forme posologique d'administration contrôlée offrant des taux de libération variables, composée 1) d'un noyau de comprimé bicouche ou multicouche dont au moins une des couches contient un ou plusieurs agents actifs et au moins une des couches contient un ou plusieurs polymères de contrôle du taux de libération, et 2) d'une enveloppe essentiellement insoluble s'étendant sur le noyau de comprimé, couvrant la majorité de la surface du comprimé, mais laissant une partie d'une couche du noyau de comprimé exposée (couche exposée), ladite enveloppe résultant du dépôt électrostatique d'une poudre contenant des particules fusibles sur le noyau de comprimé et de la fusion des particules de manière à former une couche mince.
Collins Janine Clare
Langridge John Richard
Tian Wei
Gierczak Eugene J. A.
Phoqus Pharmaceuticals Limited
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