Controlled expansion sphincter augmentation media

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/77 (2006.01) A61K 9/16 (2006.01) A61K 31/79 (2006.01) A61L 27/14 (2006.01) A61L 27/16 (2006.01) A61L 27/18 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2207075

A composition for injecting into tissues surrounding the urethra or ureter. It comprises a plurality of physiologically acceptable solid polymer particles dispersed in a physiologically acceptable biodissipatable liquid carrier. The polymer comprises a hydrophilic component. The solid polymer particles are a glycerine insoluble poly(ethylene oxide) (PEO) polymer or copolymer or a mineral oil insoluble polyvinylpyrrolidone polymer or copolymer. The plurality of solid polymer particles are capable of hydrating and upon hydration of absorbing at least about 30% water and of swelling to a predetermined volume. The solid particles are substantially insoluble in body fluids and substantially insoluble in and non-swellable by the liquid carrier. The composition is especially suitable in treating patients with urinary incontinence and patients with vesicoureteral reflux via injection into the tissues around the urethra or ureter.

Composition à injecter dans les tissus entourant l'urètre ou l'uretère. Elle comprend diverses particules de polymère solides acceptables sur le plan physiologique en suspension dans un milieu liquide pouvant se disperser dans l'organisme. Le polymère comprend un élément hydrophile. Les particules de polymère solides sont composées d'un polymère ou d'un copolymère de poly(oxyde d'éthylène) insoluble dans la glycérine ou d'un polymère ou d'un copolymère de polyvinylpyrrolidone insoluble dans l'huile minérale. Ces particules peuvent s'hydrater et ainsi absorber au moins 30 % d'eau et gonfler jusqu'à un volume prédéterminé. Elles sont pratiquement insolubles dans les liquides organiques et pratiquement insolubles et non susceptibles de gonfler dans le milieu liquide. La composition, injectée dans les tissus entourant l'urètre ou l'uretère, convient particulièrement au traitement des patients souffrant d'incontinence urinaire et de reflux vésico-urétéral.

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