Controlled onset and sustained release dosage forms and the...

Details Controlled onset and sustained release dosage forms and the... Controlled onset and sustained release dosage forms and the...

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2314298

A pharmaceutical composition for controlled onset and sustained release of an active ingredient, the composition comprising: (i) a core comprising: (a) an active ingredient; (b) a hydrophilic carrier; (c) a hydrodynamic diffusion enhancer; and optionally; (d) conventional pharmaceutically acceptable excipients selected from the group consisting of binders, fillers and lubricants and combinations thereof; and (ii) a functional coating membrane surrounding said core. The pharmaceutical composition optionally further comprises a seal coating membrane between (i) the core and (ii) the functional coating membrane and a top coating membrane surrounding (ii) the functional coating membrane. The active ingredient is released from the pharmaceutical composition over a time period of preferably between about 6 and about 24 hours after a predetermined time delay of preferably between about 30 minutes and about 6 hours after administration of the composition.

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