Controlled oxidation of microbially produced cysteine-...

Details Controlled oxidation of microbially produced cysteine-... Controlled oxidation of microbially produced cysteine-...

C - Chemistry, Metallurgy

07

K

167/140, 530/15.

C07K 14/55 (2006.01) C07K 1/113 (2006.01) C07K 1/36 (2006.01) C07K 14/565 (2006.01)

Patent

CA 1233172

Abstract of the Disclosure Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic INF-.beta. or synthetic IL- 2, in a controlled manner so that the synthetic proteins have the same disulfide bridging as their native counterparts. The oxidation employs o-iodosobenzoate as oxidizing agent and is carried out in an aqueous medium at a pH at least about one-half pH unit less than the pKa of the cystines to be oxidized, a synthetic protein concentration of less than about 5 mg/ml, and an oxidizing agent:protein mol ratio that is at least stoichiometric, provided that the oxidizing agent is in excess in the terminal portion of the reaction.

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