Controlled oxygen/anti-microbial release films

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/46 (2006.01) A01N 25/34 (2006.01) A01N 37/16 (2006.01) A01N 59/14 (2006.01) A61L 2/16 (2006.01) A61L 2/20 (2006.01) A61L 15/44 (2006.01) A61L 31/00 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2163123

A film for releasing at least one of an antimicrobial agent, oxygen, and a medicament includes a flexi- ble, porous layer (18) such as a wo- ven, non-woven, or knitted cloth or a layer of open cell foam. A first dry reagent (12) and a second dry reagent (14) which react in the pres- ence of a dilutant to form the anti- microbial agent, oxygen, or medica- ment attached to the flexible, porous layer. In one preferred embodiment, the two dry reagents are disposed on opposite sides of the flexible, porous layer such that the flexible porous layer keeps the two apart and pre- vents a premature reaction. Porous outer layers (20, 22) prevent the pow- dered reagents from being wiped off while permitting dilutant access. In a preferred embodiment, the powdered reagents include acetylsalicylic acid and a perborate which react in the presence of water to generate per- acetic acid (an antimicrobial agent which breaks down in a matter of minutes to hours into oxygen) and salicylic acid (a topical keratotic). The rate at which the reaction occurs and the peracetic acid breaks down into oxygen is controlled by buffering the pH of the pow- dered reagents, by selectively micro-encapsulating the powdered reagents, by controlling the porosity of the layers, or the like. Optionally, surfactants, detergents, emollients, gels, and the like can be added to the dry reagents. Alternately, a single reagent which releases oxygen or forms a strong oxidant may be used.

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