A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/18 (2006.01) A61K 38/45 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2146572
A buffered intravesicular pharmaceutical dosage system for delivery of TGF.alpha.PE40ab to a human bladder for bladder cancer chemotherapy, in which a buffer system of 100 mM phosphate at an initial pH of 7.8 maintains a pH range in the bladder of 6.5 to 7.8 that is sufficient to maximize interaction of TGF.alpha.PE40ab with the EGF receptor expressed on the sur- face of bladder cancer cells and to prevent aggregation of the TGF.alpha.PE40ab while in the bladder.
Marquis-Omer Dorothy
Middaugh C. Russel
Sanyal Gautam
Merck & Co. Inc.
Robic
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