Controlled porosity osmotic pump

Details Controlled porosity osmotic pump Controlled porosity osmotic pump

A - Human Necessities

61

K

128/104

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 31/55 (2006.01) A61M 31/00 (2006.01)

Patent

CA 1320885

IX137Y TITLE OF THE INVENTION CONTROLLED POROSITY OSMOTIC PUMP ABSTRACT OF THE DISCLOSURE The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a therapeutically effective amount of diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by (B) a rate controlling water insoluble wall, having a fluid permeability of 6.96 x 10 18 to 6.96 x 10 14 cm3 sec/g and a reflection coefficient of less than 0.5, prepared from: Fl 7404S/5385A - i - IX137Y (i) a polymer permeable to water but impermeable to solute and (ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall. The instant invention is also directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which does not maintain its integrity in the environment of use; and (II) a multiple of tiny osmotic pump elements, as described above.

578059

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