C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/54 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 49/22 (2006.01) C07C 231/24 (2006.01)
Patent
CA 2107164
ABSTRACT The present invention is directed to a composition comprised of a co-precipitation of a relatively solvent- soluble organic material and a relatively solvent-insoluble organic material, said relatively solvent-soluble organic material being selectively dissolved to produce a void- containing particle. In a preferred embodiment, the voids are filled with air. A preferred relatively solvent- soluble organic material is carboxylic acid such as benzoic acid, salicylic acid, or diatrizoic acid. A preferred relatively solvent-insoluble organic material is an ester of diatrizoic acid, such as the ethyl ester thereof. The present invention is further directed to a method of making a void-containing particle, comprising co- precipitating a relatively solvent-soluble organic material and a relatively solvent-insoluble organic material under conditions and for a time sufficient to form a co- precipitate, and contacting said co-precipitate with a solvent for a time and under conditions sufficient to dissolve said relatively solvent-soluble organic material to form a void-containing particle. In a preferred embodiment, the void-containing particle is freeze-dried for a time and under conditions sufficient to fill said voids with air. The present invention is further directed to a method of diagnosis comprised of administering to a mammal a contrast-effective amount of a void-containing or air- containing particle described above, and generating a diagnostic image of said mammal.
Illig Carl R.
Liversidge Gary G.
Mcintire Gregory L.
Vanorman Barbara B.
Fetherstonhaugh & Co.
Nanosystems L.l.c.
LandOfFree
Controlled precipitation of particulate diagnostic imaging... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled precipitation of particulate diagnostic imaging..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled precipitation of particulate diagnostic imaging... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1709986