Controlled release complex formulation for oral...

A - Human Necessities – 61 – K

Patent

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A61K 9/22 (2006.01)

Patent

CA 2592173

A controlled release combination formulation for oral administration comprising a) a controlled release portion containing metformin or a pharmaceutically acceptable salt thereof as an active ingredient, and a combination of a polyethylene oxide and a natural gum as a carrier for controlled release; and b) a rapid-release portion containing a sulfonylurea- based medicine for treating diabetes as an active ingredient coated on the controlled release portion is useful for the treatment of diabetes, for it is capable of maintaining an effective concentration of the medicines in blood at a constant level.

L'invention concerne une formulation combinée à libération contrôlée destinée à une administration orale comprenant a) une partie à libération contrôlée contenant de la metformine ou un sel de celle-ci acceptable sur le plan pharmaceutique en tant que principe actif, et une combinaison d'un oxyde de polyéthylène et une gomme végétale en tant que support pour la libération contrôlée; et b) une partie à libération rapide contenant un médicament à base de sulfonylurée en vue de traiter le diabète en tant que principe actif, revêtu sur la partie à libération contrôlée, et utile dans le traitement du diabète, pour sa capacité à maintenir une concentration efficace des médicaments dans le sens à un niveau constant.

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