A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/163
A61K 47/44 (2006.01) A61K 9/127 (2006.01)
Patent
CA 1296631
22819-547 ABSTRACT OF THE DISCLOSURE A controlled-release composition for a biologically active material, wherein said active material has been dissolved or dispersed in an L2-phase comprising (a) at least one monoglyceride of an unsaturated fatty acid having 16-22 carbon atoms or a vegetable or animal oil containing such a monoglyceride, (b) at least one triglyceride of at least one unsaturated fatty acid having 16 22 carbon atoms or a vegetable or animal oil containing such triglycerides, and (c) at least one polar liquid selected from the group consisting of water, glycerol, ethylene glycol and propylene glycol Such L2-phases are known per se but are novel in this context. The composition is prepared by forming the L2-phase and adding the biologically active material before, during or after the formation of the L2- phase. For sensitive substances such as proteins a mixture of the mono- and triglycerides is added dropwisely to a solution of said substance in the polar liquid. The composition is thermodynamically stable and has no tendency to separate with time. It has distinct hydrophilic and hydrophobic domains, which enables it to solubilize both water-soluble and water-insoluble compounds. The composition is useful for encapsulating a biologically active material, such as pharmaceutical compounds, pesticides, fertilizers and feromones, to obtain a preparation giving a controlled release of the encapsulated material.
538239
Engstrom Sven
Larsson Kare Viktor
Lindman Bjorn
Drilletten Ab
Fetherstonhaugh & Co.
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