Controlled-release compositions

Details Controlled-release compositions Controlled-release compositions

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61J 3/07 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 47/36 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2503361

A solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coat formed over the core and having the agent dispersed in a second controlled-release matrix from which release of the agent is relatively fast. The first matrix can be a cross-linked high amylose starch and the second matrix can be a mixture of polyvinyl acetate and polyvinylpyrrolidone.

Formulation à dosage solide possédant un noyau avec un agent pharmacologique dispersé dans une première matrice à libération contrôlée qui libère l'agent d'une manière relativement lente, et revêtement formé sur le noyau et dans lequel l'agent pharmacologique est dispersé dans une deuxième matrice à libération relativement rapide. La première matrice peut être un amidon réticulé à haute teneur en amylose, et la deuxième matrice peut être un mélange d'acétate de polyvinyle et de polyvinylpyrrolidone.

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