Controlled release compositions

Details Controlled release compositions Controlled release compositions

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2533592

The compositions disclosed herein are for use as controlled release therapeutics for the treatment of a wide variety of diseases. In particular, the compositions provide water soluble bioactive agents, organic ions and polymers where the bioactive agent is efficiently released over time with minimal degradation products. The resulting controlled release composition is capable of administration in a decreased dose volume due to the high drug content and predominance of non-degraded bioactive agent after release. Additionally, the compositions, of the present invention are capable of long term, sustained releases.

L'invention concerne des compositions destinées à être utilisées sous la forme de médicaments à libération contrôlée en traitement de diverses maladies. Ces compositions comprennent en particulier des agents bioactifs solubles dans l'eau, des ions organiques et des polymères, l'agent bioactif étant libéré de manière efficace au fur et à mesure avec un minimum de produits de dégradation. La composition à libération contrôlée selon l'invention peut être administrée en doses de volume réduit en raison de la teneur élevée en médicament et de la prédominance d'agent bioactif non dégradé après libération. Par ailleurs, les compositions selon l'invention permettent d'obtenir des libérations prolongées à long terme.

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