A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/113 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 38/21 (2006.01) A61K 47/34 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2594434
The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an in-jectable liquid which may have self-gelling properties, or of a solid implant. The inven-tion further provides a pharmaceutical kit comprising the composition, methods for pre-paring the composition, and the pharmaceutical uses relating thereto.
La présente invention porte sur une préparation pharmaceutique permettant la libération contrôlée de composés actifs relativement toxiques, en particulier de protéines bioactives de la classe des interférons. La préparation comprend un copolymère bloc biodégradable construit à partir de poly(téréphtalate d~éthylène glycol) (PEGT) et de poly(téréphtalate de butylène) (PBT). La préparation se présente sous forme de microparticules injectables, d'une solution injectable qui peut être auto-gélifiante, ou d'un implant solide. La présente invention porte en outre sur un kit pharmaceutique comprenant la préparation, des méthodes d'élaboration de la préparation, et les applications pharmaceutiques correspondantes.
Bechet Anne Chantal
Bezemer Jeroen Mattijs
Stigter Martin
Van Dijkhuizen-Radersma Riemke
Biolex Therapeutics Inc.
Borden Ladner Gervais Llp
Octoplus Sciences B.v.
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