A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/52 (2006.01) A61K 9/22 (2006.01)
Patent
CA 2627951
The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
La présente invention concerne une composition à libération contrôlée comprenant une combinaison de dinitrate d~isosorbide et d~hydralazine (hydrochlorure d~hydralazine, par exemple). Ladite composition délivre le médicament par impulsions ou de manière multimodale pour traiter l~angine, la maladie cardiaque ischémique, l~hypertension artérielle et des maladies apparentées. Le dinitrate d~isosorbide et l~hydrochlorure d~hydralazine sont de préférence libérés de la forme posologique selon un profil de libération par érosion, diffusion et/ou osmose.
Hamm Sharon
Rekhi Gurvinder
Sidwell Richard
Elan Pharma International Limited
Kirby Eades Gale Baker
LandOfFree
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