A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01)
Patent
CA 2627948
The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
L'invention a pour objet une composition à libération contrôlée, contenant une combinaison de dinitrate d'isosorbide et d~hydralazine, comme chlorhydrate d'hydralazine, qui en action libère le médicament d~une manière pulsée ou multimodale pour traiter une angine de poitrine, une maladie ischémique du coeur, une hypertension artérielle et des états pathologiques associés. De préférence, le dinitrate d'isosorbide et le chlorhydrate d'hydralazine peuvent être libérés de la forme galénique selon un profil de libération contrôlée par érosion, diffusion et/ou osmotique.
Hamm Sharon
Rekhi Gurvinder
Sidwell Richard
Elan Pharma International Limited
Kirby Eades Gale Baker
LandOfFree
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