Controlled release compositions comprising coated pellets...

A - Human Necessities – 61 – K

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A61K 9/50 (2006.01)

Patent

CA 2491355

An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.

La présente invention concerne une composition améliorée permettant de contrôler le profil de libération d'un principe actif à travers le tube digestif, ladite composition comprenant des particules, notamment des pastilles qui contiennent le principe actif et sont revêtues d'une substance de revêtement dont la dissolution dépend du pH ou d'une substance polyméthacrylate dont la dissolution dépend de préférence du pH, pour avoir une certaine épaisseur qui diffère selon l'emplacement et la vitesse de libération souhaitée pour le principe actif. Dans des compositions préférées, au moins deux pluralités de particules dans chacune desquelles les particules sont revêtues de substance de revêtement dont la dissolution dépend du pH ou de substance polyméthacrylate pour avoir une certaine épaisseur différente d'une pluralité à l'autre, sont contenues dans une capsule entièrement revêtue et permettent la libération du principe actif en différents emplacements souhaités du tube digestif.

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