Controlled-release compositions containing opioid agonist...

Details Controlled-release compositions containing opioid agonist... Controlled-release compositions containing opioid agonist...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61F 9/02 (2006.01) A61K 9/00 (2006.01) A61K 9/02 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/22 (2006.01) A61K 9/26 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 9/54 (2006.01) A61K 31/44 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2400578

Controlled-release dosage forms containing an opioid agonist; and opioid antagonist; and a controlled release material release during a dosing interval an analgesic or sub-analgesic amount of the opioid agonist along with an amount of said opioid antagonist effective to attenuate a side effect of said opioid agonist. The dosage form provides analgesia for at least about 8 hours when administered to human patients. In other embodiments, the dose of antagonist released during the dosing interval enhances the analgesic potency of the opioid agonist.

L'invention porte sur une présentation à libération régulée, contenant: un agoniste de l'opioïde, un antagoniste de l'opioïde, et un matériau régulant la libération. Ladite présentation libère, pendant les intervalles entre prises, une quantité analgésique ou sous-analgésique de l'agoniste de l'opioïde, et une quantité de l'antagoniste de l'opioïde suffisante pour atténuer les effets secondaires de l'agoniste. La présentation a un effet analgésique pendant environ 8 heures lorsqu'administrée à l'homme. Dans d'autres exécutions, la dose d'antagoniste libérée pendant les intervalles entre prises accroît le pouvoir analgésique de l'agoniste.

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