Controlled release delivery device comprising an organosol coat

Details Controlled release delivery device comprising an organosol coat Controlled release delivery device comprising an organosol coat

A - Human Necessities

61

K

A61K 9/36 (2006.01) A61J 3/00 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/62 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2648280

A controlled release delivery device for controlled release of an active ingredient comprising: (i) a core particle comprising the active ingredient homogenously dispersed or dissolved therein; and (ii) an organosol polymeric coat comprising a homogenous mixture of, (a) a water soluble gel forming polymer and a water insoluble organosoluble polymer in a dry weight ratio of from about 20:80 to about 50:50, (b) an organosolvent, and (c) an anti-tacking agent; the organosol polymeric coat being applied directly to and substantially enveloping the core particle.

L'invention concerne un dispositif d'administration à libération commandée destiné à libérer un principe actif de manière commandée. Ce dispositif comprend: (i) une particule noyau comprenant le principe actif dispersé ou dissout de manière homogène dans ce noyau; et (ii) un enrobage polymère organosol comprenant un mélange homogène de (a) un polymère formant gel soluble dans l'eau et un polymère organosoluble insoluble dans l'eau dans un rapport pondéral à sec de 20:80 environ à 50:50 environ, (b) un organosolvant, et (c) un agent antiadhésif; l'enrobage polymère organosol étant directement appliqué sur la particule de noyau et enveloppant sensiblement cette particule.

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