Controlled-release delivery device, method for producing...

Details Controlled-release delivery device, method for producing... Controlled-release delivery device, method for producing...

A - Human Necessities

61

K

167/171

A61K 47/44 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2001600

ABSTRACT An improved, controlled-release delivery device is comprised of a biologically active agent dispersed in a biodegradable lipid matrix. The agent-lipid matrix is in the form of microparticles. Because the lipid matrix exists as a solid at body temperature and because of its small size, the lipid delivery device has a high tolerance for the acid/enzyme environment of the GI tract. When administered by oral ingestion, the delivery device protects the GI tract from local irritation by the biologically active agent and promotes a high and uniform degree of bioavailability of the agent to the host.

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