Controlled release devices and methods for delivery of...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01)

Patent

CA 2758260

Embodiments of the invention include devices and methods for the delivery of nucleic acids. In an embodiment the invention includes a controlled release device including a polymeric matrix and a nucleic acid delivery construct disposed within the polymeric matrix. The nucleic acid delivery construct can include a nucleic acid molecule and a peptide molecule. The nucleic acid delivery construct can be configured to exhibit elution properties of a peptide from the polymeric matrix. The polymeric matrix can be configured to elute the nucleic acid delivery construct. Other embodiments are included herein.

Cette invention concerne des dispositifs et des méthodes d'administration d'acides nucléiques. Dans un mode de réalisation, l'invention comporte un dispositif à libération contrôlée contenant une matrice polymère et une construction libérant un acide nucléique placée à l'intérieur de la matrice polymère. La construction libérant l'acide nucléique peut comporter une molécule d'acide nucléique et une molécule peptidique. La construction libérant l'acide nucléique peut être configurée pour présenter des propriétés d'élution d'un peptide de la matrice polymère. La matrice polymère peut être configurée pour éluer la construction libérant l'acide nucléique. L'invention concerne d'autres modes de réalisation.

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