A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2664641
Disclosed is a tacrolimus sustained-release preparation which comprises a tacrolimus solid dispersion and at least a sustained-release base material (excluding a substance used for the formation of the solid dispersion) which is selected from the group consisting of a water-soluble polymer, a gum base material and a film-forming agent. The tacrolimus sustained-release preparation has an extremely excellent sustained-release property and shows a stable blood level.
L'invention concerne une préparation à libération entretenue de tacrolimus comportant une dispersion solide de tacrolimus et au moins une matière de base à libération entretenue (à l'exclusion d'une substance utilisée pour la formation de la dispersion solide) choisie dans le groupe constitué par un polymère soluble dans l'eau, une matière de base de gomme et un agent filmogène. La préparation à libération entretenue de tacrolimus présente une excellente propriété de libération entretenue et un niveau sanguin stable.
Ishii Takuya
Kojima Hiroyuki
Kondo Hiromu
Taketani Yuko
Yoshihara Keiichi
Astellas Pharma Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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