Controlled release dosage forms

Details Controlled release dosage forms Controlled release dosage forms

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/44 (2006.01) A61K 31/195 (2006.01) A61K 31/216 (2006.01) A61K 31/4045 (2006.01) A61K 31/433 (2006.01) A61K 31/663 (2006.01) A61K 45/06 (2006.01) B30B 11/34 (2006.01)

Patent

CA 2477701

A zero-order release pharmaceutical dosage form for oral administration to a patient comprising a core tablet sheathed in an annular body of compressed powder or granular material is provided. A preferred embodiment of the zero- order release pharmaceutical dosage form is a solid pharmaceutical dosage form which reduces contact of the active ingredient in solid form with the mucosa lining the gastrointestinal tract, which is particularly advantageous for delivering an ulcerative drug. A process for making the zero-order release pharmaceutical dosage form are also provided.

L'invention porte sur une forme posologique pharmaceutique à libération d'ordre zéro pour une administration orale à un patient. Cette forme comprend un micro comprimé enveloppé dans un corps annulaire de poudre comprimée ou de matériau granulaire. Un mode de réalisation préféré de la forme posologique pharmaceutique à libération d'ordre zéro consiste en une forme posologique pharmaceutique solide qui réduit le contact de l'ingrédient actif sous forme solide avec la muqueuse qui recouvre le tractus gastro-intestinal, ce qui présente un réel avantage dans l'administration d'un médicament anti-ulcéreux. L'invention concerne aussi un procédé de fabrication de la forme posologique à libération d'ordre zéro.

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