A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/166, 167/169
A61K 9/36 (2006.01) A61K 9/32 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2040471
EUR-90013 CA CONTROLLED RLEASE DRUG FORMULATION ABSTRACT The invention provides a targeted drug release formulation for delivery of drugs to the small intestine and colon of a mammal consisting essentially of a plurality of multidose units each said unit having a particle size of less than about 5mm and consisting essentially of a core of a drug (free of aminosalicylic acid functional groups and excluding anti-inflammatory and antiphlogistic drugs having a local action in the intestine, corticosteroids for the local treatment of chronic intestinal inflammation or irritation, and peppermint oil) surrounded by two membranes, one membrane consisting essentially of a pH dependent polymer which is substantially soluble a' a pH greater than about 5.0, and the second of said membranes consisting essentially of one or more polymers such that said second membrane is substantially insoluble in but permeable to gastriointestinal fluids. Said formulation is characterised by the release of no more than about 10% drug into the stomach with all of the remainder of the drug being released in the small intestine and/or colon in a period from about 2 hour to about 8 hours.
Brunetti Gabriele
Calanchi Massimo Maria
Giorgetti Enzo
Zema Marco
Eurand International S.p.a.
Ridout & Maybee Llp
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