Controlled release formulation comprising gnrh-ii

Details Controlled release formulation comprising gnrh-ii Controlled release formulation comprising gnrh-ii

A - Human Necessities

61

K

A61K 38/09 (2006.01) A61K 9/16 (2006.01) A61K 47/34 (2006.01) C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2353798

A pharmaceutical formulation for the controlled release of a therapeutic peptide or a salt thereof, which peptide has the sequence pyroGlu-His-Trp-Ser- Xaa1-Gly-Xaa2-Xaa3-Pro-Gly-NH2 wherein Xaa1 is His or Tyr, Xaa2 is Trp or Leu, and Xaa3 is Tyr or Arg, provided that when Xaa1 is Tyr and Xaa2 is Leu, then Xaa3 is not Arg, and which formulation further comprises a pharmaceutically acceptable biodegradable polymer. The formulation can be used for treating bone and prostate disorders.

Cette formule pharmaceutique est destinée à la libération prolongée d'un peptide thérapeutique, ou d'un sel de celui-ci, lequel peptide possède la séquence pyroGlu-His-Trp-Ser-Xaa?1¿Gly-Xaa?2¿-Xaa?3¿-Pro-Gly-NH¿2? Dans laquelle Xaa?1¿ représente His ou Tyr, Xaa?2¿ représente Trp ou Leu, et Xaa?3¿ représente Tyr ou Arg, à condition que lorsque Xaa?1¿ représente Tyr et Xaa?2¿ représente Leu, alors Xaa?3¿ ne représente pas Arg, et elle comprend en outre un polymère biodégradable, acceptable sur le plan pharmacologique. On peut utiliser cette formule pour traiter des troubles des os et de la prostate.

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