Controlled release formulation of lamotrigine

A - Human Necessities – 61 – K

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Details

A61K 31/53 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2488868

Rapidly disintegrating multiparticulate controlled release formulations of lamotrigine having an improved pharmacokinetic profile and improved patient compliance, and process of preparing the formulations. It provides better control of blood plasma levels than conventional tablet formulations that is administered once or more times a day.

La présente invention concerne des formulations multiparticulaires à libération contrôlée de lamotrigine à désintégration rapide présentant un profil pharmacocinétique amélioré et une meilleure tolérance du patient. L'invention concerne également un procédé pour l'élaboration de ces formulations. L'invention permet une meilleure régulation des niveaux de plasma sanguin que les formulations conventionnelles en comprimés administrés une seule fois ou plusieurs fois par jour.

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