Controlled-release formulations

Details Controlled-release formulations Controlled-release formulations

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/137 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2658170

Disclosed herein are controlled-release formulations which exhibit substantially zero-order release kinetics. The formulations include a core comprising a core active agent and a wax excipient substantially coated with an extended-release coating. The formulation optionally includes an immediate-release portion comprising an immediate-release active agent in the form of, for example, a coating disposed on at least a portion of the core. Further disclosed are fexofenadine/pseudoephedrine combination formulations, which exhibit substantially no food effect.

L'invention concerne des formulations à libération contrôlée qui présentent une cinétique de libération de l'ordre de sensiblement zéro. Les formulations comprennent un noyau incluant un agent actif de noyau et un excipient de cire, enrobé de façon substantielle par un enrobage à libération prolongée. La formulation comprend facultativement une partie à libération immédiate incluant un agent actif à libération immédiate, par exemple sous la forme d'un enrobage disposé sur au moins une partie du noyau. L'invention concerne en outre des formulations de combinaison fexofénadine/pseudoéphédrine, qui ne présentent pratiquement pas d'effet alimentaire.

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