Controlled release formulations

Details Controlled release formulations Controlled release formulations

A - Human Necessities

61

K

A61K 9/52 (2006.01) A61K 9/50 (2006.01) A61K 9/62 (2006.01) A61K 31/60 (2006.01) A61K 31/606 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2302585

A method for producing a controlled release composition is provided. A solution of a film-forming composition comprising a mixture of a substantially water-insoluble film-forming polymer and amylose in a solvent system comprising (1) water and (2) a water-miscible organic solvent which on its own is capable of dissolving the film-forming polymer is contacted with an active material and the resulting composition dried. The weight ratio of amylose to film-forming insoluble polymer in the film-forming composition is in the range 1:2 to 3:2 and the organic solvent comprises at least 50 % by weight of the solvent system. The composition is particularly suitable for delivering therapeutic agents to the colon.

La présente invention concerne un procédé permettant de produire une composition à libération contrôlée, procédé selon lequel on met en contact avec une substance active une solution de composition filmogène comprenant un mélange d'un polymère filmogène sensiblement non soluble dans l'eau et d'amylose dans un système solvant comprenant (1) de l'eau et (2) un solvant organique miscible avec l'eau capable de lui-même de dissoudre le polymère filmogène, et on déshydrate la composition résultante. Le rapport en poids de l'amylose et du polymère filmogène insoluble dans la composition filmogène est compris entre 1:2 et 3:2 et le solvant organique comprend au moins 50 % en poids du système de solvant. Cette composition est particulièrement adaptée à la délivrance d'agents thérapeutiques dans le côlon.

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