Controlled release formulations and associated methods

Details Controlled release formulations and associated methods Controlled release formulations and associated methods

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 31/167 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2657913

A pharmaceutical formulation having a geometric configuration that affects the release characteristics of active agents contained therein and associated methods are provided. In one aspect, a sustained release oral dosage pharmaceutical tablet (10) may include a first layer (12) having a first active agent, where the first layer (12) is disposed between two adjacent controlled release layers (14), at least one of the adjacent layers (14) including at least one second active agent. The two adjacent layers (14) are arranged such that they cover a portion of the first layer (12). The two adjacent layers (14) may be separate layers or they may be joined into a single continuous layer, depending on the overall configuration and geometric design of the oral dosage form.

L'invention concerne une formulation pharmaceutique dont la configuration géométrique affecte les caractéristiques de libération d'agents actifs contenus dans celle-ci ; l'invention concerne egalement des procédés associés. Dans un aspect, un comprimé pharmaceutique (10) pour administration orale à libération contrôlée peut comporter une première couche (12) incluant un premier agent actif, la première couche (12) étant disposée entre deux couches adjacentes (14) à libération contrôlée, au moins l'une des couches adjacentes (14) incluant au moins un second agent actif. Les deux couches adjacentes (14) sont disposées de telle sorte qu'elles recouvrent une partie de la première couche (12). Les deux couches adjacentes (14) peuvent être des couches séparées ou réunies en une couche continue unique, selon la configuration globale et l'agencement géométrique dans la forme posologique orale.

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