Controlled release formulations comprising uncoated discrete...

A - Human Necessities – 61 – K

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A61K 9/26 (2006.01)

Patent

CA 2648495

A controlled-release formulation comprising one or more distinct and discrete units located in physical juxtaposition to enable administration to a patient in need of treatment in a single dose, characterised in that the or each unit comprise(s): (i) a unit dose of an active pharmaceutical ingredient or pharmaceutically acceptable salt thereof; (ii) one or more extended-release agent(s); and, optionally, (iii) one or more pharmaceutically acceptable excipients, wherein the sum of the unit dose(s) constitutes a pharmaceutically effective amount of the active pharmaceutical ingredient.

L'invention concerne une formulation à libération contrôlée qui comprend une ou plusieurs unités distinctes et discrètes physiquement juxtaposées, pour permettre une administration à un patient nécessitant un traitement en une seule dose, caractérisée en ce que l'unité ou chacune des unités comprend : (i) une dose unitaire d'un principe pharmaceutique actif ou de son sel pharmaceutiquement acceptable; (ii) un ou plusieurs agents de libération retardée; et, facultativement, (iii) un ou plusieurs excipients pharmaceutiquement acceptables, la somme des doses unitaires constituant une quantité pharmaceutiquement efficace du principe pharmaceutique actif.

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