A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/198 (2006.01) A61K 9/14 (2006.01) A61K 9/24 (2006.01) A61P 25/16 (2006.01)
Patent
CA 2711014
The current invention provides a controlled release oral solid formulation of levodopa comprising levodopa, a decarboxylase inhibitor, and a carboxylic acid. Also provided by this invention is multiparticulate, controlled release oral solid for-mulations of levodopa comprising: i) a controlled release component comprising a mixture of levodopa, a decarboxylase inhibitor and a rate controlling excipient; ii) a carboxylic acid component; and iii) an immediate release component comprising a mixture of levodopa and a decarboxylase inhibitor.
La présente invention porte sur une formulation solide orale à libération contrôlée de lévodopa contenant de la lévodopa, un inhibiteur de décarboxylase et un acide carboxylique. L'invention porte également sur des formulations solides orales à libération contrôlée, multiparticulaires, de lévodopa, comprenant : i) un composant à libération contrôlée qui comporte un mélange de lévodopa, un inhibiteur de décarboxylase et un excipient de contrôle de vitesse; ii) un composant acide carboxylique, et iii) un composant à libération immédiate formé d'un mélange de lévodopa et d'un inhibiteur de décarboxylase.
Alani Laman Lynn
Hsu Ann
Kou Jim H.
Cassan Maclean
Impax Laboratories Inc.
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